CX-5461 [1138549-36-6]

MedChem Express

CX-5461 [1138549-36-6]

10

1138549-36-6

98%

C27H27N7O2S

513.61

CX-5461 is a potent and oral rRNA synthesis inhibitor. It inhibits RNA polymerase I-driven transcription of rRNA with IC50s of 142, 113, and 54 nM in HCT-116, A375, and MIA PaCa-2 cells, respectively.

CC1=NC=C(CNC(C2=C3N(C4=NC(N5CCN(CCC5)C)=CC=C4C2=O)C6=C(S3)C=CC=C6)=O)N=C1

2°C to 8°C,-20°C,-80°C

12352200