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ProductsBack/Cytostatin [457070-06-3, 682329-63-1]
Chemical Structure
Chemical Structure
Chemical Structure

Cytostatin [457070-06-3, 682329-63-1]

Research Use Only
AG-CN2-0093
AdipoGen Life Sciences
Estimated Purity>75% (HPLC)
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Product group Chemicals
Molecular Weight450.4
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Cytostatin [457070-06-3, 682329-63-1]
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    >75% (HPLC)
  • Hazard Information
    Non-hazardous,Warning
  • Molecular Formula
    C21H32NaO7P
  • Molecular Weight
    450.4
  • Scientific Description
    Chemical. CAS: 457070-06-3 - 682329-63-1 (free base). Formula: C21H32NaO7P. MW: 450.4. Isolated from Streptomyces sp. MJ654-NF4. Potent and selective protein phosphatase 2A (PP2A) inhibitor. Cell adhesion inhibitor. Inhibits the adhesion of B16 melanoma cells to laminin and collagen type IV in a dose dependent manner but not to fibronectin. Antitumor agent. Antimetastatic. Apoptosis inducer. - Potent and selective protein phosphatase 2A (PP2A) inhibitor [4-7]. Cell adhesion inhibitor [1]. Inhibits the adhesion of B16 melanoma cells to laminin and collagen type IV in a dose dependent manner but not to fibronectin [2]. Antitumor agent. Antimetastatic [2, 7]. Apoptosis inducer [3].
  • SMILES
    [Na+].C\C=C\C=C/C=C\C(O)C(C)C(CCC(C)C1OC(=O)C=CC1C)OP(O)([O-])=O
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Cytostatin, a novel inhibitor of cell adhesion to components of extracellular matrix produced by Streptomyces sp. MJ654-NF4. I. Taxonomy, fermentation, isolation and biological activities: M. Amemiya, et al.; J. Antibiot. 47, 536 (1994)
  • Inhibitory effect of cytostatin on spontaneous lung metastases of B16-BL6 melanoma cells: T. Masuda, et al.; J. Antibiot. 48, 528 (1995)
  • Screening for apoptosis inducers in microbial products and induction of apoptosis by cytostatin: K. Yamazaki, et al.; J. Antibiot. 48, 1138 (1995)
  • Cytostatin, an inhibitor of cell adhesion to extracellular matrix, selectively inhibits protein phosphatase 2A: M. Kawada, et al.; Biochim. Biophys. Acta 1452, 209 (1999)
  • Small-molecule inhibitors of Ser/Thr protein phosphatases: specificity, use and common forms of abuse: M.R. Swingle, et al.; Methods Mol. Biol. 365, 23 (2007)
  • Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and (beta12-beta13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors: M.R. Swingle, et al.; J. Pharmacol. Exp. Ther. 331, 45 (2009)
  • Rubratoxin A specifically and potently inhibits protein phosphatase 2A and suppresses cancer metastasis: S. Wada, et al.; Cancer Sci. 101, 743 (2010)