D-alpha-Hydroxyglutaric acid disodium [103404-90-6]
HY-100542
CAS Number103404-90-6
Product group Chemicals
Estimated Purity95%
Molecular Weight192.08
Overview
- SupplierMedChem Express
- Product NameD-alpha-Hydroxyglutaric acid disodium [103404-90-6]
- Delivery Days Customer10
- CAS Number103404-90-6
- Estimated Purity95%
- Molecular FormulaC5H6Na2O5
- Molecular Weight192.08
- Scientific DescriptionD-alpha-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-alpha-Hydroxyglutaric acid disodium is a weak competitive antagonist of alpha-ketoglutarate (alpha-KG) and inhibits multiple alpha-KG-dependent dioxygenases with a Ki of 10.87 mM. D-alpha-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-alpha-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling.
- SMILESO=C(O[Na])[C@H](O)CCC(O[Na])=O
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200