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ProductsBack/DABPH [1392835-67-4]
Chemical Structure
Chemical Structure
Chemical Structure

DABPH [1392835-67-4]

Research Use Only
AG-CR1-3906
AdipoGen Life Sciences
CAS Number1392835-67-4
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Product group Chemicals
Estimated Purity>98%
Molecular Weight270.3
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    DABPH [1392835-67-4]
  • Delivery Days Customer
    10
  • CAS Number
    1392835-67-4
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Non-hazardous
  • Molecular Formula
    C16H18N2O2
  • Molecular Weight
    270.3
  • Scientific Description
    Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =12nM). Displays high selectivity over HDAC1 (IC50=6.8microM). Neuroprotective. Effectively prevents neuronal cell death upon oxidative stress induction by HCA and selectively induces cellular alpha-tubulin hyperacetylation. HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration. - Chemical. CAS: 1392835-67-4. Formula: C16H18N2O2. MW: 270.3. Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =12nM). Displays high selectivity over HDAC1 (IC50=6.8microM). Neuroprotective. Effectively prevents neuronal cell death upon oxidative stress induction by HCA and selectively induces cellular alpha-tubulin hyperacetylation. HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.
  • SMILES
    CN(C)C1=CC=C(CC2=CC=C(C=C2)C(=O)NO)C=C1
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Bicyclic-capped histone deacetylase 6 inhibitors with improved activity in a model of axonal charcot-marie-tooth disease: S. Shen, et al.; ACS Chemical Neuroscience (submitted) (2015)