Dapivirine [244767-67-7]

MedChem Express

Dapivirine [244767-67-7]

10

244767-67-7

Research Use Only

99.23%

C20H19N5

329.4

Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI). Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations.

CC1=CC(C)=CC(C)=C1NC2=CC=NC(NC3=CC=C(C#N)C=C3)=N2

2°C to 8°C,-20°C,-80°C

12352200