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DAPT [208255-80-5]

Research Use Only
HY-13027
MedChem Express
CAS Number208255-80-5
Product group Chemicals
Estimated Purity99.62%
Molecular Weight432.46
Price on request
Packing Size
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Overview

  • Supplier
    MedChem Express
  • Product Name
    DAPT [208255-80-5]
  • Delivery Days Customer
    10
  • CAS Number
    208255-80-5
  • Certification
    Research Use Only
  • Estimated Purity
    99.62%
  • Molecular Formula
    C23H26F2N2O4
  • Molecular Weight
    432.46
  • Scientific Description
    DAPT (GSI-IX) is a potent and orally active gamma-secretase inhibitor with IC50s of 115 nM and 200 nM for total amyloid-beta (Abeta) and Abeta42, respectively. DAPT inhibits the activation of Notch 1 signaling and induces cell differentiation. DAPT also induces autophagy and apoptosis. DAPT has neuroprotection activity and has the potential for autoimmune and lymphoproliferative diseases, degenerative disease and cancers treatment.
  • SMILES
    FC1=CC(F)=CC(CC(N[C@H](C(N[C@H](C(OC(C)(C)C)=O)C2=CC=CC=C2)=O)C)=O)=C1
  • Storage Instruction
    2°C to 8°C,-20°C,-80°C
  • UNSPSC
    12352200