Ripretinib [1442472-39-0]
HY-112306
CAS Number1442472-39-0
Product group Chemicals
Estimated Purity98.05%
Molecular Weight510.36
Overview
- SupplierMedChem Express
- Product NameRipretinib [1442472-39-0]
- Delivery Days Customer10
- CAS Number1442472-39-0
- Estimated Purity98.05%
- Molecular FormulaC24H21BrFN5O2
- Molecular Weight510.36
- Scientific DescriptionRipretinib (DCC-2618) is an orally bioavailable, selective KIT and PDGFRA switch-control inhibitor. Ripretinib (DCC-2618) targets and binds to both wild-type and mutant forms of KIT and PDGFRA specifically at their switch pocket binding sites, thereby preventing the switch from inactive to active conformations of these kinases and inactivating their wild-type and mutant forms. Ripretinib (DCC-2618) also inhibits multiple other kinase targets, such as FLT3 and KDR (or VEGFR-2). DCC-2618 exerts antineoplastic effect and induces apoptosis.
- SMILESO=C(NC1=CC(C2=CC3=C(C=C(NC)N=C3)N(CC)C2=O)=C(Br)C=C1F)NC4=CC=CC=C4
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200