Decitabine, Free Base [2353-33-5]

Biorbyt

Decitabine, Free Base [2353-33-5]

16

2353-33-5

Research Use Only

>99%

C8H12N4O4

228.21 g/mol

Decitabine is a cytosine nucleoside analog and inhibits further DNA methylation after incorporated into DNA. Decitabine has shown activity in some hematologic disorders including myelodysplastic syndromes (MDS), acute myelogenous leukemia (AML) and chronic myelogenous leukemia (CML). Treatment of patients with sickle cell disease (SSD) with subcutaneous decitabine increased fetal hemoglobin (HbF) levels and improved SSD pathophysiology such as red cell adhesion, endothelial damage, and coagulation pathway activity without cytotoxicity.

-20°C or -80°C

12352200