Dexamethasone [50-02-2]

Catalog number: HY-14648_10mM
Brand: MedChem Express
Packing: 10 mM
Other sizes: 1 g
5 g
Price: On Request
Expected delivery time: 10 days
Quantity:

Product specifications for - Dexamethasone [50-02-2]

Overview: 
Product group: Chemicals
Category: Other
CAS No.: 50-02-2
Properties: 
Purity: >98%
Molecular Formula: C22H29FO5
Molecular weight: 392.46
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: Dexamethasone(MK 125, NSC 34521, Prednisolone F) is a potent synthetic member of the glucocorticoid class of steroid drugs that has anti-inflammatory and immunosuppressant properties. IC50 Value: 58 nM (HECM-induced eosinophil survival) [1] Target: in vitro: DEX in concentrations from 1 to 100uM did not change LDH release but exposure to 10uM and 100uM DEX for 24, 48 and 72h caused a significant reduction in cell viability and proliferation as confirmed by MTT reduction and BrdU ELISA assays, respectively [2]. Dex impaired neuron and oligodendrocyte maturation in PUFA-supplemented cells, demonstrated by the reduction of neurite lengths and oligodendrocyte sizes [3]. in vivo: The levels of IL-17, IL-6 and Tim-3 were substantially increased and the IL-10 level decreased in BALF in the asthmatic mice, which was significantly reversed by DEX treatment [4]. An IM bolus injection of DEX sodium phosphate in pigs resulted in a fast and complete absorption, with a mean maximal plasma concentration of 80.94+/-21.29ng/mL at 0.35+/-0.21h and a high absolute bioavailability of 131.06+/-26.05% [5]. Clinical trial: PANORAMA-1: Panobinostat or Placebo With Bortezomib and Dexamethasone in Patients With Relapsed Multiple Myeloma. Phase 3
Safety information: 
MSDS: MSDS