Dexamethasone phosphate disodium [2392-39-4]

Catalog number: HY-B1829A_100mg
Brand: MedChem Express
Packing: 100 mg
Other sizes: 10 mM
500 mg
Price: € 79.00
Expected delivery time: 10 days
Quantity:

Product specifications for - Dexamethasone phosphate disodium [2392-39-4]

Overview: 
Product group: Chemicals
Category: Other
CAS No.: 2392-39-4
Properties: 
Molecular Formula: C22H28FNa2O8P
Molecular weight: 516.40
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: Dexamethasone phosphate disodium is a glucocorticoid receptor agonist. IC50 & Target: Glucocorticoid receptor[1] In Vitro: Dexamethasone regulates several transcription factors, including activator protein-1, nuclear factor-AT, and nuclear factor-kB, leading to the activation and repression of key genes involved in the inflammatory response[1]. Dexamethasone potently inhibits granulocyte-macrophage colony stimulating factor (GM-CSF) release from A549 cells with EC50 of 2.2 nM. Dexamethasone (EC50=36 nM) induces transcription of the beta2-receptor is found to correlate with glucocorticoid receptor (GR) DNA binding and occurred at 10-100 fold higher concentrations than the inhibition of GM-CSF release. Dexamethasone (IC50=0.5 nM) inhibits a 3xkappaB (NF-kappaB, IkappaBalpha, and I-kappaBbeta), which is associated with inhibition of GM-CSF release[2]. In Vivo: Treatment with Dexamethasone at a dose of 2x5 mg/kg efficiently inhibits lipopolysaccharide (LPS)-induced inflammation. In our experimental system, treatment with a single dose of Dexamethasone 10 mg/kg (i.p.) significantly decreases recruitment of granulocytes as well as spontaneous production of oxygen radicals compared with animals expose to LPS and injected with solvent alone (saline). The effects are statistically significant when administered both 1 h before and 1 h after inhalation of LPS. The number of granulocytes in BALF decreased to levels comparable to healthy animals (given an aerosol of water)[3]. Rats treated with Dexamethasone consume less food and weighed less than control rats. Treated rats also weigh less than pair-fed animals though their food intake is similar. Five days of Dexamethasone injection result in a significant increase in both the liver mass (+42%) and the liver to body weight ratio (+65%). The wet weight of gastrocnemius muscle decreases 20% after 5 days of treatment, but it remains unaffected relative to body weight (g/100 g body weight), indicating that muscle weight loss paralleled body weight loss[4].
Safety information: 
MSDS: MSDS