Dolutegravir sodium [1051375-19-9]
HY-13238A
CAS Number1051375-19-9
Product group Chemicals
Estimated Purity99.88%
Molecular Weight441.36
Overview
- SupplierMedChem Express
- Product NameDolutegravir sodium [1051375-19-9]
- Delivery Days Customer10
- CAS Number1051375-19-9
- CertificationResearch Use Only
- Estimated Purity99.88%
- Molecular FormulaC20H18F2N3NaO5
- Molecular Weight441.36
- Scientific DescriptionDolutegravir sodium (S/GSK1349572 sodium) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir sodium (S/GSK1349572 sodium) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir sodium (S/GSK1349572 sodium) retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM).
- SMILESO=C(C1=CN(C2=C(O[Na])C1=O)C[C@]3([H])OCC[C@@H](C)N3C2=O)NCC4=CC=C(F)C=C4F
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200