E 2012 [870843-42-8]

MedChem Express

E 2012 [870843-42-8]

10

870843-42-8

Research Use Only

97.39%

C25H26FN3O2

419.49

E 2012 is a potent gamma (gamma) secretase modulator without affecting Notch processing. E 2012 inhibits 3beta-hydroxysterol delta24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimers disease by reduction of amyloid beta-42, and induces cataract following repeated doses in the rat.

O=C(N([C@H](C1=CC=C(C=C1)F)C)CCC/2)C2=C\C3=CC=C(N4C=NC(C)=C4)C(OC)=C3

2°C to 8°C,-20°C,-80°C

12352200