Elafibranor [923978-27-2]

Catalog number: HY-16737_100mg
Brand: MedChem Express
Packing: 100 mg
Other sizes: 5 mg
10 mM
10 mg
50 mg
Price: € 824.00
Expected delivery time: 10 days

Product specifications for - Elafibranor [923978-27-2]

Product group: Chemicals
Category: Inhibitors / activators
CAS No.: 923978-27-2
Purity: >98%
Molecular Formula: C22H24O4S
Molecular weight: 384.4886
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: Elafibranor (GFT505) is an agonist of the peroxisome proliferator-activated receptor(PPAR)-alpha and -delta, induces resolution of nonalcoholic steatohepatitis without fibrosis worsening. Target: PPAR Elafibranor is an agonist of the peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-delta. Elafibranor improves insulin sensitivity, glucose homeostasis, and lipid metabolism and reduces inflammation.We assessed the safety and efficacy of elafibranor in an international, randomized, double-blind placebo-controlled trial of patients with nonalcoholic steatohepatitis (NASH). Elafibranor (GFT505) is a dual PPARalpha/delta agonist that has demonstrated efficacy in disease models of nonalcoholic fatty liver disease (NAFLD)/NASH and liver fibrosis. Elafibranor confers liver protection by acting on several pathways involved in NASH pathogenesis, reducing steatosis, inflammation, and fibrosis.[1]
Safety information: 
Additional information: 
Synonyms: HY-16737; GFT505; GFT-505; GFT 505