ENMD-2076 [934353-76-1]

Selleck Chemicals

ENMD-2076 [934353-76-1]

9

934353-76-1

Research Use Only

ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to RET, SRC, NTRK1/TRKA, CSF1R/FMS, VEGFR2/KDR, FGFR and PDGFRalfa. ENMD-2076 inhibits the growth of a wide range of human solid tumor and hematopoietic cancer cell lines with IC50 from 0.025 to 0.7 muM, which induces apoptosis and G2/M phase arrest. Phase 2.

12352200