Entrectinib [1108743-60-7]

MedChem Express

Entrectinib [1108743-60-7]

9

1108743-60-7

Research Use Only

98.13%

C31H34F2N6O2

560.64

Entrectinib (NMS-E628) is an orally active and centrally active inhibitor of TrkA/B/C, ROS1 and ALK, with IC50 values of 1, 3, 5, 12 and 7 nM, respectively. Entrectinib induces apoptosis and cycle arrest in cancer cells, has antitumor activity, and attenuates bleomycin-induced lung fibrosis in mice.

O=C(NC1=NNC2=C1C=C(CC3=CC(F)=CC(F)=C3)C=C2)C4=C(NC5CCOCC5)C=C(N6CCN(C)CC6)C=C4

2°C to 8°C,-20°C,-80°C

12352200