Tazemetostat [1403254-99-8]
HY-13803
Overview
- SupplierMedChem Express
- Product NameTazemetostat [1403254-99-8]
- Delivery Days Customer10
- CAS Number1403254-99-8
- CertificationResearch Use Only
- Estimated Purity98%
- Molecular FormulaC34H44N4O4
- Molecular Weight572.74
- Scientific DescriptionTazemetostat (EPZ-6438) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat (EPZ-6438) inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a Ki value of 2.5 nM. Tazemetostat (EPZ-6438) inhibits EZH2 with IC50s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat (EPZ-6438) inhibits rat EZH2 with an IC50 of 4 nM. Tazemetostat (EPZ-6438) also inhibits EZH1 with an IC50 of 392 nM.
- SMILESO=C(C1=CC(C2=CC=C(CN3CCOCC3)C=C2)=CC(N(CC)C4CCOCC4)=C1C)NCC5=C(C)C=C(C)NC5=O
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200