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Tazemetostat [1403254-99-8]

Research Use Only
HY-13803
MedChem Express
CAS Number1403254-99-8
Product group Chemicals
Estimated Purity98%
Molecular Weight572.74
Price on request
Packing Size
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Tazemetostat [1403254-99-8]
  • Delivery Days Customer
    10
  • CAS Number
    1403254-99-8
  • Certification
    Research Use Only
  • Estimated Purity
    98%
  • Molecular Formula
    C34H44N4O4
  • Molecular Weight
    572.74
  • Scientific Description
    Tazemetostat (EPZ-6438) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat (EPZ-6438) inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a Ki value of 2.5 nM. Tazemetostat (EPZ-6438) inhibits EZH2 with IC50s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat (EPZ-6438) inhibits rat EZH2 with an IC50 of 4 nM. Tazemetostat (EPZ-6438) also inhibits EZH1 with an IC50 of 392 nM.
  • SMILES
    O=C(C1=CC(C2=CC=C(CN3CCOCC3)C=C2)=CC(N(CC)C4CCOCC4)=C1C)NCC5=C(C)C=C(C)NC5=O
  • Storage Instruction
    2°C to 8°C,-20°C,-80°C
  • UNSPSC
    12352200