Erastin [571203-78-6]
HY-15763
CAS Number571203-78-6
Product group Chemicals
Estimated Purity98.46%
Molecular Weight547.04
Overview
- SupplierMedChem Express
- Product NameErastin [571203-78-6]
- Delivery Days Customer10
- CAS Number571203-78-6
- Estimated Purity98.46%
- Molecular FormulaC30H31ClN4O4
- Molecular Weight547.04
- Scientific DescriptionErastin is a ferroptosis inducer. Erastin shows selective cytotoxicity, targeting cells expressing oncogenic mutants of RAS. Erastin exhibits the mechanism of ferroptosis induction related to ROS and iron-dependent signaling. Erastin inhibits voltage-dependent anion channels (VDAC2/VDAC3) and accelerates oxidation, leading to the accumulation of endogenous reactive oxygen species. Erastin also disrupts mitochondrial permeability transition pore (mPTP) with anti-tumor activity.
- SMILESO=C1N(C2=CC=CC=C2OCC)C(C(N3CCN(C(COC4=CC=C(Cl)C=C4)=O)CC3)C)=NC5=C1C=CC=C5
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352200