Exendin-4 [141758-74-9]

Catalog number: HY-13443_10mg
Brand: MedChem Express
Packing: 10 mg
Other sizes: 1 mg
5 mg
25 mg
10 mM
Price: € 252.90 € 281.00
Expected delivery time: 10 days

Product specifications for - Exendin-4 [141758-74-9]

Product group: Chemicals
Category: Other
CAS No.: 141758-74-9
Purity: >98%
Molecular Formula: C184H282N50O60S
Molecular weight: 4186.57188
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: Exendin-4, a 39 amino acid peptide, is a long-acting glucagon-like peptide-1 receptor agonist with an IC50 of 3.22 nM. IC50 & Target: IC50: 3.22 nM (glucagon-like peptide-1 receptor)[1] In Vitro: In human umbilical vein endothelial cells, exendin-4 significantly increases NO production, endothelial NO synthase (eNOS) phosphorylation, and GTP cyclohydrolase 1 (GTPCH1) level in a dose-dependent manner[2]. Exendin-4 shows cytotoxic effects to MCF-7 breast cancer cells with IC50 of 5 uM at 48 hour[3]. In Vivo: Both low- and high-dose exendin-4 treatment in ob/ob mice improve serum ALT and reduce serum glucose, insulin levels and calculated HOMA scores compared with control. Exendin-4-treated ob/ob mice sustain a marked reduction in the net weight gain in the final 4 weeks of the study period[4]. Animals treated with exendin-4 have more pancreatic acinar inflammation, more pyknotic nuclei and weigh significantly less than control rats. Exendin-4 treatment is associated with lower insulin and leptin levels as well as lower HOMA values in rats[5]. Exenatide causes dose-dependent relaxation of rat thoracic aorta, which is evoked via the GLP-1 receptor and is mediated mainly by H2S but also by NO and CO[6].
Safety information: 
Additional information: 
Synonyms: HY-13443; Exenatide
Lithium and an EPAC-specific inhibitor ESI-09 synergistically suppress pancreatic cancer cell proliferation and survival', Wang X. Acta Biochim Biophys Sin (Shanghai). 2017 May 5:1-8. Read more