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Chemical Structure
Chemical Structure
Chemical Structure

FK-866 [658084-64-1]

Research Use Only
AG-CR1-0011
AdipoGen Life Sciences
CAS Number658084-64-1
Product group Chemicals
Estimated Purity>98% (NMR)
Molecular Weight391.5
Price on request
Packing Size
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    FK-866 [658084-64-1]
  • Delivery Days Customer
    10
  • CAS Number
    658084-64-1
  • Certification
    Research Use Only
  • Estimated Purity
    >98% (NMR)
  • Hazard Information
    Non-hazardous,Warning
  • Molecular Formula
    C24H29N3O2
  • Molecular Weight
    391.5
  • Scientific Description
    Chemical. CAS: 658084-64-1. Formula: C24H29N3O2. MW: 391.5. Nampt/visfatin inhibitor. Inhibitor of NAD+ biosynthesis. Inhibits the enzyme/substrate complex and the free enzyme (Ki = 0.4 nM and Ki = 0.3 nM, respectively). Apoptosis inducer. Autophagy inducer. Causes premature senescence. Angiogenesis inhibitor. - Nampt/visfatin inhibitor [1]. Inhibitor of NAD+ biosynthesis [1]. Inhibits the enzyme/substrate complex and the free enzyme (Ki = 0.4 nM and Ki = 0.3 nM, respectively) [1]. Apoptosis inducer [1]. Autophagy inducer [2]. Causes premature senescence [3]. Angiogenesis inhibitor [4].
  • SMILES
    O=C(NCCCCC1CCN(CC1)C(=O)C1=CC=CC=C1)\C=C\C1=CC=CN=C1
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis: M. Hasmann & I. Schemainda; Cancer Res. 63, 7436 (2003)
  • NAD depletion by FK866 induces autophagy: R.A. Billington, et al.; Autophagy 4, 385 (2008)
  • Extension of human cell lifespan by nicotinamide phosphoribosyltransferase: E. van der Veer, et al.; J. Biol. Chem. 282, 10841 (2007)
  • Antiangiogenic potency of FK866/K22.175, a new inhibitor of intracellular NAD biosynthesis, in murine renal cell carcinoma: J. Drevs, et al.; Anticancer Res. 23, 4853 (2003)