Flavopiridol (L86-8275) [146426-40-6]
S1230
Product group Chemicals
Overview
- SupplierSelleck Chemicals
- Product NameFlavopiridol (L86-8275) [146426-40-6]
- Delivery Days Customer9
- CertificationResearch Use Only
- Scientific DescriptionFlavopiridol (L86-8275, Alvocidib, NSC 649890, HMR-1275) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4, CDK6, and CDK9 with IC50 values in the 20-100 nM range. It is more selective for CDK1, 2, 4, 6, 9 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol induces autophagy and ER stress. Flavopiridol blocks HIV-1 replication. Phase 1/2.
- UNSPSC12352200