Chemical Structure
FTY720 . hydrochloride [162359-56-0]
AG-CR1-3587
Estimated Purity>98%
Product group Chemicals
Molecular Weight307.4 . 36.5
Overview
- SupplierAdipoGen Life Sciences
- Product NameFTY720 . hydrochloride [162359-56-0]
- Delivery Days Customer10
- CertificationResearch Use Only
- Estimated Purity>98%
- Hazard InformationNon-hazardous,Warning
- Molecular FormulaC19H33NO2 . HCl
- Molecular Weight307.4 . 36.5
- Scientific DescriptionCell permeable immunosuppressor displaying lymphocyte sequestration properties and used for treatment in multiple sclerosis. Potent sphingosine 1-phosphate (S1P) receptor (S1P1, S1P3, S1P4, and S1P5) agonist when phosphorylated by sphingosine kinase. Sphingosine transporter Abcb1 and leukotriene C4 transporter Abcc1 activity enhancer. Cytosolic phospholipase A2 inhibitor, independent of sphingosine 1-phosphate receptors. Shown to induce autophagy and apoptosis. - Chemical. CAS: 162359-56-0. Formula: C19H33NO2 . HCl. MW: 307.4 . 36.5. Synthetic analog of ISP-1, isolated from Isaria sinclairii. Cell permeable immunosuppressor displaying lymphocyte sequestration properties and used for treatment in multiple sclerosis. Potent sphingosine 1-phosphate (S1P) receptor (S1P1, S1P3, S1P4, and S1P5) agonist when phosphorylated by sphingosine kinase. Sphingosine transporter Abcb1 and leukotriene C4 transporter Abcc1 activity enhancer. Cytosolic phospholipase A2 inhibitor, independent of sphingosine 1-phosphate receptors. Autophagy inducer. Apoptosis inducer.
- SMILES[Cl-].CCCCCCCCC1=CC=C(CCC([NH3+])(CO)CO)C=C1
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352200
References
- FTY720: Altered lymphocyte traffic results in allograft protection: V. Brinkmann, et al.; Transplantation 72, 764 (2001)
- The immune modulator FTY720 targets sphingosine 1-phosphate receptors: V. Brinkmann, et al.; J. Biol. Chem. 277, 21453 (2002)
- FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes: S.M. Honig, et al.; J. Clin. Invest. 111, 627 (2003)
- Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1: M. Matloubian, et al.; Nature 427, 355 (2004)
- The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors: S.G. Payne, et al.; Blood 109, 1077 (2007)
- Fingolimod (FTY720): a recently approved multiple sclerosis drug based on a fungal secondary metabolite: C.R. Strader, et al.; J. Nat. Prod. 74, 900 (2011)
- Autophagy induced by FTY720 promotes apoptosis in U266 cells: A. Liao, et al.; Eur. J. Pharm. Sci. 45, 600 (2012)
- Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma: A. Estrada-Bernal, et al.; Neuro Oncol. 14, 405 (2012)