Inavolisib [2060571-02-8]

MedChem Express

Inavolisib [2060571-02-8]

10

2060571-02-8

Research Use Only

98%

C18H19F2N5O4

407.37

GDC-0077 (RG6114) is a potent, orally available, and selective PI3Kalpha inhibitor (IC50=0.038 nM). GDC-0077 (RG6114) exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. GDC-0077 (RG6114) is more selective for mutant versus wild-type PI3Kalpha.

C[C@@H](C(N)=O)NC1=CC=C(C2=NC(N3[C@H](C(F)F)COC3=O)=CN2CCO4)C4=C1

2°C to 8°C,-20°C,-80°C

12352200