GDC-0623 [1168091-68-6]

MedChem Express

GDC-0623 [1168091-68-6]

10

1168091-68-6

Research Use Only

95%

C16H14FIN4O3

456.21

GDC-0623 (RG 7421) is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki=0.13 nM, +ATP), and displays 6-fold weaker potency against HCT116 (KRAS (G13D), EC50=42 nM) versus A375 (BRAFV600E, EC50=7 nM).

FC(C=C(I)C=C1)=C1NC2=C(C(NOCCO)=O)C=CC3=CN=CN23

2°C to 8°C,-20°C,-80°C

12352200