GDC-0834 [1133432-49-1]

MedChem Express

GDC-0834 [1133432-49-1]

10

1133432-49-1

Research Use Only

98.05%

C33H36N6O3S

596.74

GDC-0834 is a potent and selective BTK inhibitor. GDC-0834 inhibits BTK with an in vitro IC50 of 5.9 and 6.4 nM in biochemical and cellular assays, respectively, and in vivo IC50 of 1.1 and 5.6 microM in mouse and rat, respectively.

O=C(C1=CC(CCCC2)=C2S1)NC3=CC=CC(C(N=C4NC5=CC=C([C@H]6N(C)CCN(C)C6=O)C=C5)=CN(C)C4=O)=C3C

2°C to 8°C,-20°C,-80°C

12352200