GGTI298 [180977-44-0]

MedChem Express

GGTI298 [180977-44-0]

10

180977-44-0

C27H33N3O3S

479.63

GGTI298 is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, strongly inhibiting the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras, with IC50 values of 3 and > 20 microM in vivo, respectively.

CC(C)C[C@@H](C(OC)=O)NC(C1=CC=C(NC[C@@H](N)CS)C=C1C2=C3C=CC=CC3=CC=C2)=O

2°C to 8°C,-20°C,-80°C

12352200