GNF-5 [778277-15-9]

MedChem Express

GNF-5 [778277-15-9]

10

778277-15-9

Research Use Only

99.42%

C20H17F3N4O3

418.37

GNF-5, the N-hydroxyethyl carboxamide analog of GNF-2, is an orally active Bcr-Abl inhibitor. GNF-5 has Bcr-Abl inhibition activity with an IC50 value of 0.22 microM. GNF-5 has good favorable pharmacokinetic properties. GNF-5 can be used for the research of kinds of cancer including chronic myelogenous leukemia (CML) and breast cancer.

FC(F)(F)OC(C=C1)=CC=C1NC2=NC=NC(C3=CC=CC(C(NCCO)=O)=C3)=C2

2°C to 8°C,-20°C,-80°C

12352200