GSK1904529A [1089283-49-7]

MedChem Express

GSK1904529A [1089283-49-7]

10

1089283-49-7

Research Use Only

99.66%

C44H47F2N9O5S

851.96

GSK1904529A is a potent, selective, orally active, and ATP-competitive inhibitor of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR), with IC50s of 27 and 25 nM, respectively. GSK1904529A shows poor activity (IC50>1 microM) in 45 other serine/threonine and tyrosine kinases. GSK1904529A exhibits anti-tumor activity.

O=C(C1=CC(C2=C(N3C=CC=CC3=N2)C4=NC(NC5=CC(CC)=C(C=C5OC)N6CCC(CC6)N7CCN(CC7)S(=O)(C)=O)=NC=C4)=CC=C1OC)NC8=C(C=CC=C8F)F

2°C to 8°C,-20°C,-80°C

12352200