GSK484 hydrochloride [1652591-81-5]

MedChem Express

GSK484 hydrochloride [1652591-81-5]

10

1652591-81-5

97%

C27H32ClN5O3

510.03

GSK484 hydrochloride is a selective and reversible peptidylarginine deiminase 4 (PAD4) inhibitor. GSK484 hydrochloride demonstrates high affinity binding to PAD4 with IC50s of 50 nM in the absence of Calcium. In the presence of 2 mM Calcium, notably lower potency (250 nM) is observed.

O=C(N1C[C@H](N)[C@H](O)CC1)C2=CC(OC)=C3C(N=C(C(N4CC5CC5)=CC6=C4C=CC=C6)N3C)=C2.[H]Cl

2°C to 8°C,-20°C,-80°C

12352200