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GSK-872 [1346546-69-7]

Research Use Only
HY-101872
MedChem Express
CAS Number1346546-69-7
Product group Chemicals
Estimated Purity98%
Molecular Weight383.49
Price on request
Packing Size
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Overview

  • Supplier
    MedChem Express
  • Product Name
    GSK-872 [1346546-69-7]
  • Delivery Days Customer
    10
  • CAS Number
    1346546-69-7
  • Certification
    Research Use Only
  • Estimated Purity
    98%
  • Molecular Formula
    C19H17N3O2S2
  • Molecular Weight
    383.49
  • Scientific Description
    GSK-872 is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM. GSK-872 decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury.
  • SMILES
    O=S(C1=CC=C2N=CC=C(C2=C1)NC3=CC=C4SC=NC4=C3)(C(C)C)=O
  • Storage Instruction
    2°C to 8°C,-20°C,-80°C
  • UNSPSC
    12352200