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ProductsBack/GW1929 [196808-24-9]
Chemical Structure
Chemical Structure
Chemical Structure

GW1929 [196808-24-9]

Research Use Only
AG-CR1-0116
AdipoGen Life Sciences
CAS Number196808-24-9
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Product group Chemicals
Estimated Purity>98% (NMR)
Molecular Weight495.6
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    GW1929 [196808-24-9]
  • Delivery Days Customer
    10
  • CAS Number
    196808-24-9
  • Certification
    Research Use Only
  • Estimated Purity
    >98% (NMR)
  • Hazard Information
    Non-hazardous
  • Molecular Formula
    C30H29N3O4
  • Molecular Weight
    495.6
  • Scientific Description
    Chemical. CAS: 196808-24-9. Formula: C30H29N3O4. MW: 495.6. Potent and subtype-selective (>1000-fold) PPARgamma agonist. Angiogenesis inhibitor. Apoptosis inhibitor. Anti-inflammatory. Anti-hyperglycemic and anti-hyperlipidemic agent. Antidiabetic. The glucose-lowering effect in rats is 100-fold more potent than that of troglitazone. - Potent and subtype-selective (>1000-fold) PPARgamma agonist [1]. Angiogenesis inhibitor [3]. Apoptosis inhibitor [4]. Anti-inflammatory [4]. Anti-hyperglycemic and anti-hyperlipidemic agent [1]. Antidiabetic. The glucose-lowering effect in rats is 100-fold more potent than that of troglitazone [2].
  • SMILES
    COC1=CC(=O)OC(=C1)C1C2(O)CC3OC(=O)[C@]2(O)C(C(=O)C2=CC=CC=C2)C1(O)C3O
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents: B.R. Henke, et al.; J. Med. Chem. 41, 5020 (1998)
  • A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat: K.K. Brown, et al.; Diabetes 48, 1415 (1999)
  • PPARgamma agonists inhibit angiogenesis by suppressing PKCalpha- and CREB-mediated COX-2 expression in the human endothelium: E. Scoditti, et al.; Cardiovasc. Res. 86, 302 (2010)
  • Ameliorative Effects of GW1929, a Nonthiazolidinedione PPAR gamma Agonist, on Inflammation and Apoptosis in Focal Cerebral Ischemic-Reperfusion Injury: R.K. Kaundal & S.S. Sharma; Curr. Neurovasc. Res. 8, 236 (2011)