Olverembatinib [1257628-77-5]

MedChem Express

Olverembatinib [1257628-77-5]

10

1257628-77-5

Research Use Only

99.46%

C29H27F3N6O

532.56

Olverembatinib (GZD824) is a potent and orally active pan-Bcr-Abl inhibitor. Olverembatinib potently inhibits a broad spectrum of Bcr-Abl mutants. Olverembatinib strongly inhibits native Bcr-Abl and Bcr-AblT315I with IC50s of 0.34 nM and 0.68 nM, respectively. Olverembatinib has antitumor activity.

O=C(NC1=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1)C3=CC=C(C)C(C#CC4=CN=C(NN=C5)C5=C4)=C3

2°C to 8°C,-20°C,-80°C

12352200