Almonertinib hydrochloride [2134096-03-8]
HY-112823B
CAS Number2134096-03-8
Product group Chemicals
Estimated Purity98.03%
Molecular Weight562.11
Overview
- SupplierMedChem Express
- Product NameAlmonertinib hydrochloride [2134096-03-8]
- Delivery Days Customer10
- CAS Number2134096-03-8
- CertificationResearch Use Only
- Estimated Purity98.03%
- Molecular FormulaC30H36ClN7O2
- Molecular Weight562.11
- Scientific DescriptionAlmonertinib (HS-10296) hydrochloride is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib hydrochloride shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib hydrochloride is used for the research of the non-small cell lung cancer.
- SMILESCOC(C=C(N(C)CCN(C)C)C(NC(C=C)=O)=C1)=C1NC2=NC(C3=CN(C4CC4)C5=C3C=CC=C5)=CC=N2.[H]Cl
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200