INCB3344 R-isomer

MedChem Express

INCB3344 R-isomer

10

95.02%

C29H34F3N3O6

577.59

INCB3344 R-isomer is the R-isomer of INCB3344. INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity.

CCO[C@H]1CN([C@]2([H])CC[C@](C3=CC(OCO4)=C4C=C3)(O)CC2)C[C@@H]1NC(CNC(C5=CC(C(F)(F)F)=CC=C5)=O)=O

2°C to 8°C,-20°C,-80°C

12352200