Ipatasertib [1001264-89-6]
HY-15186
Overview
- SupplierMedChem Express
- Product NameIpatasertib [1001264-89-6]
- Delivery Days Customer10
- CAS Number1001264-89-6
- CertificationResearch Use Only
- Estimated Purity95%
- Molecular FormulaC24H32ClN5O2
- Molecular Weight458.0
- Scientific DescriptionIpatasertib (GDC-0068) is an orally active, highly selective and ATP-competitive pan-Akt inhibitor with IC50 values of 5, 18, 8 nM for Akt1/2/3, respectively. Ipatasertib synchronously activates FoxO3a and NF-kappaB through inhibition of Akt leading to p53-independent activation of PUMA. Ipatasertib also induces apoptosis in cancer cells and inhibits tumor growth in xenograft mouse models.
- SMILESClC1=CC=C([C@@H](CNC(C)C)C(N2CCN(C3=C([C@H](C)C[C@H]4O)C4=NC=N3)CC2)=O)C=C1
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200