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MKC8866 [1338934-59-0]

HY-104040
MedChem Express
CAS Number1338934-59-0
Product group Chemicals
Estimated Purity98.22%
Molecular Weight361.35
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Packing Size
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Overview

  • Supplier
    MedChem Express
  • Product Name
    MKC8866 [1338934-59-0]
  • Delivery Days Customer
    10
  • CAS Number
    1338934-59-0
  • Estimated Purity
    98.22%
  • Molecular Formula
    C18H19NO7
  • Molecular Weight
    361.35
  • Scientific Description
    MKC8866, a salicylaldehyde analog, is a potent, selective IRE1 RNase inhibitor with an IC50 of 0.29 microM in human vitro. MKC8866 strongly inhibits Dithiothreitol-induced X-box-binding protein 1-spliced (XBP1s) expression with an EC50 of 0.52 microM and unstresses RPMI 8226 cells with an IC50 of 0.14 microM. MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibits prostate cancer (PCa) tumor growth.
  • SMILES
    O=CC1=C(O2)C(C(C)=C(CC(N3CCOCC3)=O)C2=O)=CC(OC)=C1O
  • Storage Instruction
    2°C to 8°C,-20°C,-80°C
  • UNSPSC
    12352200