Isoliquiritigenin [961-29-5]

Catalog number: AG-CN2-0459-M010
Brand: AdipoGen Life Sciences
Packing: 10 mg
Other sizes: 50 mg
Price: € 120.00
Expected delivery time: 7 days
Chemical Structure

Product specifications for - Isoliquiritigenin [961-29-5]

Product group: Chemicals
Category: Other
Source: Synthetic. Originally isolated from Glycyrriza sp.
CAS No.: 961-29-5
Purity: >97% (HPLC)
Molecular Formula: C15H12O4
Molecular weight: 256.3
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: Anticancer. Apoptosis inducer and cell proliferation inhibitor. Autophagy inducer. Anti-angiogenic. VEGF/VEGFR-2 signaling inhibitor. Antioxidant and antibacterial. AMPK-mediated GSK3beta inhibitor. Anti-inflammatory. Inhibits translocation and activation of NF-kappaB by blocking phosphorylation and subsequent degradation of IkappaBalpha. Downregulates TRIF-dependent signaling pathways of TLRs by inhibiting TBK1 kinase activity. Blocks LPS-induced TLR4/MD2 complex signaling. NLRP3 inflammasome activation inhibitor. Inhibits NLRP3-activated ASC oligomerization. Can block the NLRP3 inflammasome at both the priming step and the activation step. H(2) histamine receptor signaling inhibitor. Anti-diabetic. Antihyperglycemic. Aldose reductase inhibitor. Vasorelaxant. Soluble guanylyl cyclase activator. GABAA receptor positive allosteric modulator. Potent cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor. Shown to inhibit breast cancer stem cells through WIF1 demethylation. Shows outstanding matrix properties for MALDI-TOF-MS analysis of oligosaccharides.
Safety information: 
Hazard information: H315, H319, H335
Additional information: 
Synonyms: AG-CN2-0459-M010; AdipoGen Life Sciences; ISL; GU 17; 4, 2', 4'-Trihydroxychalcone
The potent anti-tumor-promoting agent isoliquiritigenin: S. Yamamoto, et al.; Carcinogenesis 12, 317 (1991) Read more
Anti-platelet action of isoliquiritigenin, an aldose reductase inhibitor in licorice: M. Tawata, et al.; Eur. J. Pharmacol. 212, 87 (1992) Read more
Vasorelaxant effect of isoliquiritigenin, a novel soluble guanylate cyclase activator, in rat aorta: S.M. Yu & S.C. Kuo; Br. J. Pharmacol. 114, 1587 (1995) Read more
Antioxidant constituents from licorice roots: isolation, structure elucidation and antioxidative capacity toward LDL oxidation: J. Vaja, et al.; Free Radic. Biol. Med. 23, 302 (1997) Read more
Isoliquiritigenin inhibits cell proliferation and induces apoptosis in human hepatoma cells: Y.L. Hsu, et al.; Planta Med. 71, 130 (2005) Read more
Isoliquiritigenin induces apoptosis and cell cycle arrest through p53-dependent pathway in Hep G2 cells: Y.L. Hsu, et al.; Life Sci. 77, 279 (2005) Read more
Isoliquiritigenin selectively inhibits H(2) histamine receptor signalling: D.C. Kim, et al.; Mol. Pharmacol. 70, 493 (2006) Read more
Isoliquiritigenin inhibits IkappaB kinase activity and ROS generation to block TNF-alpha induced expression of cell adhesion molecules on human endothelial cells: S. Kumar, et al.; Biochem. Pharmacol. 73, 1602 (2007) Read more
AMPK-mediated GSK3beta inhibition by isoliquiritigenin contributes to protecting mitochondria against iron-catalyzed oxidative stress: S.H. Choi, et al.; Biochem. Pharmacol. 79, 1352 (2010) Read more
Isoliquiritigenin suppresses the Toll-interleukin-1 receptor domain-containing adapter inducing interferon-beta (TRIF)-dependent signaling pathway of Toll-like receptors by targeting TBK1: S.J. Park & H.S. Youn; J. Agric. Food Chem. 58, 4701 (2010) Read more