IWP-2 [686770-61-6]

MedChem Express

IWP-2 [686770-61-6]

10

686770-61-6

Research Use Only

95.68%

C22H18N4O2S3

466.6

IWP-2 is an inhibitor of Wnt processing and secretion with an IC50 of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. IWP-2 is also an ATP-competitive CK1delta inhibitor with an IC50 of 40 nM for the gatekeeper mutant M82FCK1delta.

O=C(NC1=NC2=CC=C(C)C=C2S1)CSC3=NC(CCS4)=C4C(N3C5=CC=CC=C5)=O

2°C to 8°C,-20°C,-80°C

12352200