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ProductsBack/IWR-1-endo [1127442-82-3]
Chemical Structure
Chemical Structure
Chemical Structure

IWR-1-endo [1127442-82-3]

Research Use Only
AG-CR1-3581
AdipoGen Life Sciences
CAS Number1127442-82-3
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Product group Chemicals
Estimated Purity>98%
Molecular Weight409.4
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    IWR-1-endo [1127442-82-3]
  • Delivery Days Customer
    10
  • CAS Number
    1127442-82-3
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Non-hazardous
  • Molecular Formula
    C25H19N3O3
  • Molecular Weight
    409.4
  • Scientific Description
    Chemical. CAS: 1127442-82-3. Formula: C25H19N3O3. MW: 409.4. Potent and reversible cell permeable Wnt pathway signaling inhibitor. Inhibits Wnt-induced accumulation of beta-catenin, leading to proteasomal degradation of this protein through a destruction complex which consists of Apc, Axin2, CK1 and GSK-3beta. Stabilizes the destruction complex, increasing the level of Axin2 protein without changing the levels of Apc or GSK-3beta. Tankyrase-1 (TNKS1/PARP5a) and Tankyrase-2 (TNKS2/PARP5b) inhibitor (in vitro auto-PARsylation assay). - Potent and reversible cell permeable Wnt pathway signaling inhibitor [1, 2, 4, 5]. Inhibits Wnt-induced accumulation of beta-catenin, leading to proteasomal degradation of this protein through a destruction complex which consists of Apc, Axin2, CK1 and GSK-3beta. Stabilizes the destruction complex, increasing the level of Axin2 protein without changing the levels of Apc or GSK-3beta. Tankyrase-1 (TNKS1/PARP5a) and Tankyrase-2 (TNKS2/PARP5b) inhibitor (in vitro auto-PARsylation assay) [3, 6].
  • SMILES
    [H][C@@]12C3CC(C=C3)[C@]1([H])C(=O)N(C2=O)C1=CC=C(C=C1)C(=O)NC1=C2N=CC=CC2=CC=C1
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer: B. Chen, et al.; Nat. Chem. Biol. 5, 100 (2009)
  • Structure-activity relationship studies of small-molecule inhibitors of Wnt response: J. Lu, et al.; Bioorg. Med. Chem. Lett. 19, 3825 (2009)
  • Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling: S.M. Huang, et al.; Nature 461, 614 (2009)
  • Wnt signaling is required for early development of zebrafish swimbladder: A. Yin, et al.; PLoS One 6, e18431 (2011)
  • Perturbation of zebrafish swimbladder development by enhancing Wnt signaling in Wif1 morphants: A. Yin, et al.; Biochim. Biophys. Acta 1823, 236 (2012)
  • Structural basis of selective inhibition of human tankyrases: M. Narwal, et al.; J. Med. Chem. 55, 1360 (2012)