JAK3-IN-1 [1805787-93-2]

MedChem Express

JAK3-IN-1 [1805787-93-2]

10

1805787-93-2

Research Use Only

99.23%

C26H30ClN7O2

508.02

JAK3-IN-1 is a potent, selective and orally active JAK3 inhibitor with an IC50 of 4.8 nM. JAK3-IN-1 shows over 180-fold more selective for JAK3 than JAK1 (IC50 of 896 nM) and JAK2 (IC50 of 1050 nM).

O=C(C=C)NC1=CC(CNC2=NC(NC3=C(OC)C=C(N4CCN(C)CC4)C=C3)=NC=C2Cl)=CC=C1

2°C to 8°C,-20°C,-80°C

12352200