JNJ-7777120 [459168-41-3]

MedChem Express

JNJ-7777120 [459168-41-3]

10

459168-41-3

Research Use Only

98%

C14H16ClN3O

277.75

JNJ-7777120 is a potent and selective histamine H4 receptor antagonist (Ki=4.5 nM). JNJ-7777120 effectively blocks histamine-induced migration of mouse tracheal mast cells from connective tissue to epithelial cells. JNJ-7777120 also significantly blocks neutrophil infiltration in a mouse Zymosan-induced peritonitis model. JNJ-7777120 has a good potential to study antipruritic and anti-inflammatory.

O=C(C(N1)=CC2=C1C=CC(Cl)=C2)N3CCN(C)CC3

2°C to 8°C,-20°C,-80°C

12352200