JZL 184 [1101854-58-3]

MedChem Express

JZL 184 [1101854-58-3]

10

1101854-58-3

Research Use Only

95%

C27H24N2O9

520.49

JZL 184 is a potent, selective and irreversible MAGL inhibitor that blocks 2-Arachidonoylglycerol (2-AG) hydrolysis in brain membranes (IC50 of 8 nM). JZL 184 displays >300-fold selectivity for MAGL over FAAH.

OC(C1=CC=C(OCO2)C2=C1)(C3CCN(C(OC4=CC=C([N+]([O-])=O)C=C4)=O)CC3)C5=CC(OCO6)=C6C=C5

2°C to 8°C,-20°C,-80°C

12352200