Ki16425 [355025-24-0]

MedChem Express

Ki16425 [355025-24-0]

10

355025-24-0

Research Use Only

98.1%

C23H23ClN2O5S

474.96

Ki16425 (Debio 0719) is a subtype-selective, competitive antagonist of the EDG-family receptors, LPA1 and LPA3 with Kis of 0.34 microM and 0.93 microM, respectively. Ki16425 (Debio 0719) reduces the LPA-induced activation of p42/p44 MAPK. Ki16425 can also inhibit LPA-induced dephosphorylation of Yes-associated protein (YAP)/TAZ in HEK293A cells.

ClC1=C(C=CC=C1)C(C)OC(NC2=C(ON=C2C)C3=CC=C(C=C3)CSCCC(O)=O)=O

2°C to 8°C,-20°C,-80°C

12352200