KML29 [1380424-42-9]

MedChem Express

KML29 [1380424-42-9]

10

1380424-42-9

Research Use Only

98.77%

C24H21F6NO7

549.42

KML29 is an extremely selective, orally active and irreversible MAGL inhibitor, with IC50 values of 15 nM, 43 nM and 5.9 nM for mouse, rat and human MAGL, respectively. KML29 exhibits minimal cross-reactivity toward other central and peripheral serine hydrolases, including no detectable activity against FAAH.

O=C(N1CCC(C(C2=CC=C(OCO3)C3=C2)(C4=CC=C(OCO5)C5=C4)O)CC1)OC(C(F)(F)F)C(F)(F)F

2°C to 8°C,-20°C,-80°C

12352200