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ProductsBack/KN-93 (water soluble) [1188890-41-6, 139298-40-1]
Chemical Structure
Chemical Structure
Chemical Structure

KN-93 (water soluble) [1188890-41-6, 139298-40-1]

Research Use Only
AG-CR1-0065
AdipoGen Life Sciences
Estimated Purity>98%
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Product group Chemicals
Molecular Weight501.0 . 98.0
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    KN-93 (water soluble) [1188890-41-6, 139298-40-1]
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Non-hazardous
  • Molecular Formula
    C26H29ClN2O4S . H3PO4
  • Molecular Weight
    501.0 . 98.0
  • Scientific Description
    Chemical. CAS: 1188890-41-6 - 139298-40-1 (free base). Formula: C26H29ClN2O4S . H3PO4. MW: 501.0 . 98.0. Selective Ca2+/calmodulin-dependent protein kinase II inhibitor. Insulin release inhibitor. Acid secretion inhibitor. G1 cell cycle arrest inducer. Apoptosis inducer. Ion channel inhibitor. ROS inducer. Androgen receptor inhibitor. - Selective Ca2+/calmodulin-dependent protein kinase II inhibitor [1]. Insulin release inhibitor [2]. Acid secretion inhibitor [3]. G1 cell cycle arrest inducer [4]. Apoptosis inducer [4, 7]. Ion channel inhibitor [5, 6]. ROS inducer [7]. Androgen receptor inhibitor [7].
  • SMILES
    OP(O)([O-])=O.COC1=CC=C(C=C1)S(=O)(=O)N(CCO)C1=C(C[NH+](C)C\C=C\C2=CC=C(Cl)C=C2)C=CC=C1
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells: M. Sumi, et al.; BBRC 181, 968 (1991)
  • Presence and possible involvement of Ca/calmodulin-dependent protein kinases in insulin release from the rat pancreatic beta cell: I. Niki, et al.; BBRC& 191, 255 (1993)
  • Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-93: N. Mamiya, et al.; BBRC 195, 608 (1993)
  • G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase): R.M. Tombes, et al.; Cell Growth Differ. 6, 1063 (1995)
  • CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of L-type calcium channels: L. Gao, et al.; BBRC 345, 1606 (2006)
  • KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels: S. Reazadeh, et al.; J. Pharmacol. Exp. Ther. 317, 292 (2006)
  • KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer: O.W. Rokhlin, et al.; Cancer Biol. Ther. 9, 224 (2010)