KS176 [1253452-78-6]

MedChem Express

KS176 [1253452-78-6]

10

1253452-78-6

Research Use Only

98.01%

C22H19N3O5

405.4

KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 (mu)M in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1.

O=C(C1=C(NC(C2=CC=C([N+]([O-])=O)C=C2)=O)C=CC=C1)NC3=CC=C(CCO)C=C3

2°C to 8°C,-20°C,-80°C

12352200