L-685458 [292632-98-5]

MedChem Express

L-685458 [292632-98-5]

10

292632-98-5

99.33%

C39H52N4O6

672.85

L-685458 is a potent transition state analog (TSA) gamma-secretase inhibitor (GSI). L-685458 inhibits amyloid beta-protein precursor gamma-secretase activity with IC50 of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested. L685458 inhibits gamma-secretase-mediated cleavage of APP-C99 and Notch-100 with IC50s of 301.3 nM and 351.3 nM, respectively. L-685458 can be used for the research of alzheimers disease (AD) and cancers.

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2°C to 8°C,-20°C,-80°C

12352200