Larotrectinib sulfate [1223405-08-0]

MedChem Express

Larotrectinib sulfate [1223405-08-0]

10

1223405-08-0

98.69%

C21H24F2N6O6S

526.51

Larotrectinib sulfate (LOXO-101 sulfate; ARRY-470 sulfate) is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C).

O=S(O)(O)=O.O=C(N1CC[C@H](O)C1)NC2=C3N=C(N4[C@@H](C5=CC(F)=CC=C5F)CCC4)C=CN3N=C2

2°C to 8°C,-20°C,-80°C

12352200