Lexibulin [917111-44-5]

MedChem Express

Lexibulin [917111-44-5]

10

917111-44-5

Research Use Only

99.5%

C24H30N6O2

434.53

Lexibulin (CYT-997) is a potent and orally active tubulin polymerisation inhibitor with IC50s of 10-100 nM in cancer cell lines; with potent cytotoxic and vascular disrupting activity in vitro and in vivo. Lexibulin induces cell apoptosis and induces mitochondrial ROS generation in GC cells.

CCC[C@H](NC1=C(C)C=NC(C2=CC=C(NC(NCC)=O)C(OC)=C2)=N1)C3=CN=CC=C3

2°C to 8°C,-20°C,-80°C

12352200