LJI308 [1627709-94-7]

MedChem Express

LJI308 [1627709-94-7]

10

1627709-94-7

Research Use Only

99.21%

C21H18F2N2O2

368.38

LJI308 is a potent pan-ribosomal S6 kinase (RSK) inhibitor, with IC50s of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively. LJI308 inhibits the phosphorylation of RSK (T359/S363) and YB-1 (S102) after irradiation, treatment with EGF, and in cells expressing a KRAS mutation.

OC1=C(F)C=C(C2=C(C3=CC=C(N4CCOCC4)C=C3)C=CN=C2)C=C1F

2°C to 8°C,-20°C,-80°C

12352200