Branaplam [1562338-42-4]

MedChem Express

Branaplam [1562338-42-4]

10

1562338-42-4

Research Use Only

95.62%

C22H27N5O2

393.48

Branaplam (LMI070; NVS-SM1) is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. Branaplam inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 microM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model.

OC1=CC(C2=CNN=C2)=CC=C1C3=CC=C(OC4CC(C)(C)NC(C)(C)C4)N=N3

2°C to 8°C,-20°C,-80°C

12352200